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KMID : 0857020140290010017
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Kosin Medical Journal
2014 Volume.29 No. 1 p.17 ~ p.22
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Diagnostic Value of Preoperative Serum Thyroglobulin Measurement for the Diagnosis of Malignancy in Follicular or Hurthle Cell Neoplasms of the Thyroid Gland
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Kim Nam-Kyu
Kang Seong-Joo
Lee Weon-Hyoung
Yeo Go-Eun
Han You-Jin
Kim Bu-Kyung
Kwon Su-Kyoung
Park Yo-Han
Choi Young-Sik
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Abstract
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Objectives: The aim of this retrospective study was whether serum Tg predicts malignancy in follicular or Hurthle-cell neoplasms on fine needle aspiration.
Methods: A chart review of 111 patients (90 females, 21 males; mean age 46.8 ± 11.9 years) with follicular or Hurthle-cell neoplasms on fine needle aspiration, who were surgically treated between Sep. 2001 and Sep. 2011, was performed. Predictive factors for malignancy were identified by the chi-squared test and multivariate logistic regression.
Results: There were no differences between 41 malignant and 70 benign lesions in serum Tg or any of the normalized indexes. Receiver-operator characteristic analysis revealed no cut-off value. Lesions with serum Tg levels greater than 500 g/L had no significant difference. And also there were no independent predictors of malignancy by multivariate logistic regression.
Conclusions: In this study, the author found that serum Tg has poor accuracy for predicting malignancy in follicular or Hurthle cell neoplasms on fine needle aspiration.
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KEYWORD
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Follicular neoplasm, Hurthle cell neoplasm, Serum thyroglobulin, Thyroid carcinoma
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